Overview

Endpoint Preclinical’s Structural Heart Procedures service delivers precision evaluation and intervention in preclinical cardiac models. We offer a comprehensive array of techniques—from valve replacement and repair to advanced device evaluation and cardiac model development—that generate reliable, reproducible data for sophisticated studies.

Our on‑site services are tailored to support diverse research models and address the complex challenges of structural heart disease and therapeutic innovation.

Structural Heart
  • Valve replacement
  • Transcatheter valves
  • Septal defect closure
  • Hemodynamic support
  • Cardiac imaging
Structural Heart
  • Valve replacement
  • Transcatheter valves
  • Septal defect closure
  • Hemodynamic support
  • Cardiac imaging

Service Highlights

Below is a selection of what we offer. If you don’t see what you’re looking for, please contact us—we can likely help.

  • Valve Replacement & Repair: Evaluation and testing of both surgical and transcatheter approaches—including TAVR, TMVR, TTVR, and TPVR—to assess valve function and durability.

  • Transcatheter Heart Valve Implantation: Expertise in deploying new‑generation valve devices and conducting transcatheter mitral valve interventions.

  • Septal Defect Closures & Balloon Valvuloplasty: Proficient in transcatheter closure of atrial and ventricular septal defects and performing balloon valvuloplasty to relieve valve stenosis.

  • Left Atrial Appendage (LAA) Closures: Assessment and procedural testing of LAA occlusion devices designed to mitigate stroke risk.

  • Percutaneous Ventricular Assist & Hemodynamic Support: Techniques including PVAD implantation and aortic balloon pump placement to provide hemodynamic support in preclinical models.

  • Stent Placements & Electrophysiology: Advanced stenting techniques for coronary and peripheral vessels, along with electrophysiological mapping for pacing, ablation, and ICD lead implantation.

  • Cardiac Model Development: Creation of robust preclinical models that replicate conditions such as heart failure and pulmonary hypertension for device validation and therapeutic evaluation.

  • Advanced Imaging Integration & Data Analysis: Utilization of echocardiography, MRI, and related modalities to quantitatively assess cardiac structures and performance, informing both device evaluation and study outcomes.

Meet our Structural Heart Experts!

Vince Mendenhall

Vince Mendenhall, DVM, PhD

World-Renowned Surgeon in Cardiovascular, Neurosurgical, and Orthopedic Procedures. View Profile

Sam Gilbert, VMD

Sam Gilbert, VMD

Expert in Advanced Surgical Techniques, Regulatory Strategy, and Medical Device Development. View Profile

Dale Groth, BS, SRS

Dale Groth, BS, SRS

Expert in Cardiac, Neurovascular & Vascular Surgery, Advanced Interventional Techniques and Disease Model Development. View Profile

Mark Urtz

Mark Urtz, BS

Expert in Interventional Procedures, Study Design, and Medical Device Testing. View Profile

Christina Gross

Christina Gross, BA, SRS

Expert in Surgical & Interventional Techniques, Cardiovascular, Transplant, and Reconstructive Procedures. View Profile

Tim Hacker, PhD

Tim Hacker, PhD

Expert in Cardiovascular Models, Advanced Sonography, and Hemodynamic Data Analysis. View Profile

Why Endpoint?

Endpoint Preclinical fuses clinical insight with research precision, ensuring that structural heart studies—from valve repair to ventricle support devices—are conducted under exacting conditions. We work with you to design robust cardiac models, integrate advanced imaging, and interpret hemodynamic data so that your device or therapy is thoroughly vetted. Our goal is to accelerate your path to meaningful cardiac research breakthroughs by providing consistent, high-quality results tailored to your unique objectives.

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