Overview

Endpoint Preclinical’s interventional and structural heart procedure services offer a comprehensive solution for cardiovascular research, with expertise in both early-stage medical device testing and advanced therapeutic studies.

Our team is proficient in performing a range of cardiovascular interventions, including valve replacement and repair, trans-catheter heart valve procedures (TAVR, TMVR, TTVR, TPVR), coronary stent implantation, aortic stent grafts, and coronary drug-coated balloon (CDCB) treatments. We also specialize in the creation of advanced models of cardiac disease, such as heart failure, myocardial infarction (MI), valve dysfunction, and pulmonary hypertension, to drive scientific discoveries.

Interventional & Structural Heart

  • Leading expertise

  • Advanced techniques

  • Medical device testing

  • Heart disease model development

  • Training

Interventional & Structural Heart

  • Leading expertise

  • Advanced techniques

  • Medical device testing

  • Heart disease model development

  • Training

Why Endpoint?

At Endpoint Preclinical, we bring together leading experts in advanced interventional and structural heart procedures, offering unparalleled expertise for cardiovascular research. Our team excels in performing complex medical device interventions and creating preclinical models of cardiovascular diseases, such as heart failure and valve dysfunction, to drive innovation in therapeutic studies. We are passionate about teaching and collaboration, working alongside your team to streamline research, fill gaps, and expand your cardiac programs to ensure they remain competitive.

Interventional & Structural Heart Procedures:

  • Valve Replacement and Repair: Specializing in surgical and trans-catheter aortic valve replacement (TAVR), mitral valve repair (TMVR), tricuspid (TTVR), and pulmonary valve repair (TPVR).
  • Transcatheter Heart Valve Implantation: Expertise in testing new-generation valves and conducting transcatheter mitral valve interventions.
  • Septal Defect Closures: Proficient in transcatheter closures of atrial and ventricular septal defects.
  • Balloon Valvuloplasty: Performing balloon procedures for valve stenosis relief in both mitral and aortic valves.
  • Left Atrial Appendage (LAA) Closures: Experienced in LAA occlusion devices and other closure techniques to reduce the risk of stroke.
  • Percutaneous Left Ventricular Assist Device (PVAD) Implantation: Proficiency in PVAD procedures for heart function support.
  • Aortic Balloon Pumps: Expertise in hemodynamic support through balloon pump placement.
  • Stent Placements: Skilled in coronary and peripheral vascular stenting techniques.
  • Electrophysiology & Cardiac Mapping: Specializing in cardiac pacing, ablation, and ICD lead implantation.
  • Pulmonary Hypertension Models: Creating specialized models to study the effectiveness of therapeutic interventions for pulmonary hypertension.
  • Heart Failure Models: Development of heart failure models to evaluate cardiac function in response to treatment or interventions.

Meet our Interventional and Structural Heart Experts!

Dale Groth

Dale Groth, BS, SRS

With almost 30 years of experience and thousands of complex procedures performed, Dale Groth is a distinguished surgical and interventional consultant in preclinical research. His career spans cardiovascular, neurovascular, and general surgery, where he has developed, refined, and executed cutting-edge surgical models. View Profile

Mark Urtz

Mark Urtz, BS

Mark Urtz brings over 30 years of experience in preclinical research, spanning both academia and industry. During his career, he has performed thousands of interventional procedures, including coronary and peripheral interventions, electrophysiology, renal denervation, valve placement, neuromodulation, and more. View Profile

Tim Hacker, PhD

Tim Hacker, PhD

Dr. Tim Hacker is a prominent figure in preclinical cardiovascular research, with over 30 years of experience in developing and studying animal models of cardiac disease. Utilizing advanced surgical and microsurgical techniques, Dr. Hacker provides clients with both surgical and data collection services directly in their labs. View Profile

Applications

Interventional and structural heart procedures are instrumental in a variety of preclinical research applications, including:

  • Medical Device Testing: Comprehensive evaluation of cardiovascular devices, from early-stage feasibility to efficacy and safety assessments.
  • Therapeutic Studies: Studying the effectiveness of pharmaceutical interventions in structural heart conditions and failure models.
  • Cardiovascular Disease Models: Creation of models that replicate disease states like heart failure and pulmonary hypertension to test novel therapies.
  • Valve Dysfunction: Exploring the effects of transcatheter and surgical interventions on valve health and function.
  • Pulmonary Hypertension: Utilizing advanced models to study the impact of interventions on pulmonary vascular resistance.

Related Services

  • Echocardiography: Our echocardiography services provide comprehensive on-site and off-site imaging, interpretation, and analysis, handling thousands of scans annually with portable systems and expert teams.

  • Ventricular Pressure-Volume Loops: We offer expert-driven PV loop data collection, analysis, and access to high-end technology, providing both on-site and off-site flexible solutions across all models.

  • ECG Analysis and Interpretation: Our ECG services handle GLP and non-GLP studies, offering caliper-based and large-scale digital telemetry formats, with full data processing and interpretation.

  • MRI Data Analysis and Interpretation: We specialize in cardiac, neuro, and musculoskeletal MRI, with clinical radiologists and veterinary cardiologist using advanced software for detailed data analysis and reporting.

  • Training: We offer both on-site and off-site training across all service areas, ensuring your team is fully equipped to perform advanced preclinical techniques.

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