Overview

Endpoint Preclinical’s Model Development service offers a comprehensive, customizable approach to designing, optimizing, and validating preclinical disease models across a broad spectrum of organ systems. Leveraging advanced surgical techniques and rigorous data analysis, our experts develop highly reproducible models that closely mimic complex human disease states.

Our portfolio spans models for cardiac dysfunction, renal and transplant scenarios, pulmonary injury, neurological disorders (including spinal cord injury), musculoskeletal and orthopedic conditions, gastrointestinal disorders, wound healing, and many additional areas—providing a robust foundation for device testing and therapeutic evaluation.

Model Development
  • Custom disease models
  • Multi-organ systems
  • Surgical model design
  • Translational research
  • High reproducibility
Model Development
  • Custom disease models
  • Multi-organ systems
  • Surgical model design
  • Translational research
  • High reproducibility

Service Highlights

Below is a selection of our offerings. If you don’t see exactly what you need, please contact us—we can likely help tailor a solution for your research.

  • Cardiac Model Development: Creation of robust models that replicate conditions such as heart failure, myocardial infarction, and valve dysfunction using advanced surgical interventions and quantitative assessments.

  • Renal & Transplant Model Development: Establishment of reproducible models for kidney and liver disease—including transplant scenarios that simulate rejection, ischemia-reperfusion injury, and graft integration.

  • Pulmonary Model Development: Development of models for pulmonary hypertension, lung injury, and related respiratory conditions to evaluate novel therapeutic approaches and device performance.

  • Neurological Model Development: Design and refinement of models simulating stroke, neurodegeneration, traumatic brain injury, and spinal cord injury through precise surgical techniques and advanced neuroimaging.

  • Musculoskeletal & Orthopedic Model Development: Creation of models for bone healing, fracture repair, and soft tissue regeneration that support orthopedic research initiatives and assess biomechanical stability.

  • Gastrointestinal Model Development: Development of models addressing digestive system disorders, including protocols for organ resection, reconstruction, and functional recovery assessment.

  • Wound Healing & Soft Tissue Model Development: Establishment of models to simulate both acute and chronic wound healing processes, providing reproducible platforms to evaluate tissue regeneration and infection management strategies.

  • Multi-System Model Integration: Development of integrated models that require coordinated interventions across multiple organ systems to enhance translational relevance.

Meet our Model Development Experts!

Vince Mendenhall

Vince Mendenhall, DVM, PhD

World-Renowned Surgeon in Cardiovascular, Neurosurgical, and Orthopedic Procedures. View Profile

Sam Gilbert, VMD

Sam Gilbert, VMD

Expert in Advanced Surgical Techniques, Regulatory Strategy, and Medical Device Development. View Profile

Dale Groth

Dale Groth, BS, SRS

Expert in Cardiac, Neurovascular & Vascular Surgery, Advanced Interventional Techniques and Disease Model Development. View Profile

Christina Gross

Christina Gross, BA, SRS

Expert in Surgical & Interventional Techniques, Cardiovascular, Transplant, and Reconstructive Procedures. View Profile

Tim Hacker, PhD

Tim Hacker, PhD

Expert in Cardiovascular Models, Advanced Sonography, and Hemodynamic Data Analysis. View Profile

Mark Urtz

Mark Urtz, BS

Expert in Interventional Procedures, Study Design, and Medical Device Testing. View Profile

Oliver Wearing, PhD

Oliver Wearing, PhD

Expert in Cardiovascular Physiology & Preclinical Microsurgery. View Profile

Yelena Akelina

Yelena Akelina, DVM, MS

Expert in Advanced Microsurgery, Model Development, and Precision Training. View Profile

Eric Adams

Eric Adams, MS, SRS

Expert in Neurosurgical Interventions, Preclinical Research, and Targeted Drug Delivery. View Profile

Why Endpoint?

Successful model development demands extensive cross-disciplinary knowledge and careful validation at each step. Endpoint Preclinical leverages decades of practice in refining and replicating disease states—from straightforward organ injury to complex multi-system pathologies. By combining surgical excellence with robust data analysis and a collaborative design process, we help you achieve models that are both translationally relevant and reproducible, fueling meaningful insights and accelerating your path to new discoveries.

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