This Expert Brief includes a practical decision framework for evaluating inflammatory findings in ocular studies and assessing their potential impact on NOAEL.

It outlines the factors that support interpretation—including immune correlation, dose response, and individual animal analysis—and highlights common gaps that can limit interpretability.

This Expert Brief was developed with input from Endpoint’s Ophthalmology expert Dr. Ryan Boyd, DVM, MS, DACVO following the webinar How to Plan IND-Enabling Ocular Studies.