Explore the biological and study design factors that most commonly complicate interpretation in preclinical ocular studies, including immune privilege, route-dependent exposure, inflammation classification, and adaptive immune responses. Includes a practical study design checklist for evaluating study interpretability from design through data analysis.

This Expert Brief was developed with input from Endpoint’s Ophthalmology expert Dr. Ryan Boyd, DVM, MS, DACVO following the webinar How to Plan IND-Enabling Ocular Studies.