Overview

Pressure-Volume (PV) Loop analysis offers a comprehensive view of both load-dependent and load-independent measures of cardiac contractility, making it an invaluable tool for understanding cardiovascular function in various physiological and pathological models. PV Loop analysis excels at capturing nuanced changes in cardiac performance that might be missed by other techniques, providing data endpoints that are uniquely accessible.

Whether you are conducting discovery studies or investigating cardiac and pulmonary functions, PV Loop analysis provides the critical data you need to advance your research.

Ventricular PV Loops
  • Leading expertise

  • LV and RV function

  • Comprehensive cardiac assessment

  • Technology access

  • World-class training

Ventricular PV Loops
  • Leading expertise

  • LV and RV function

  • Comprehensive cardiac assessment

  • Technology access

  • World-class training

Why Endpoint?

Endpoint Preclinical uniquely offers on-site PV loop data collection, data analysis, and technology rental as a flexible, turnkey service. This unique combination of deep expertise and equipment access ensures that we can meet your research needs regardless of location or infrastructure. Whether your study requires left or right ventricular assessments, or you’re investigating cardiac or pulmonary function, we can help!  

Meet our Pressure-Volume Loop Experts!

Tim Hacker, PhD

Tim Hacker, PhD

Dr. Tim Hacker is a prominent figure in preclinical cardiovascular research, with over 30 years of experience in developing and studying animal models of cardiac disease. Utilizing advanced surgical and microsurgical techniques, Dr. Hacker provides clients with both surgical and data collection services directly in their labs. View Profile

Oliver Wearing, PhD

Oliver Wearing, PhD

Oliver Wearing, PhD, brings over a decade of specialized experience in preclinical cardiovascular research. He has developed expertise in ventricular pressure-volume loop data collection and analysis, focusing on both acute and chronic cardiovascular measurements, including blood pressure, sympathetic nerve activity, and blood flow. View Profile

Applications

PV loop data can be used across multiple research areas, including:

  • Discovery: For initial insights into cardiac function across experimental models.
  • Efficacy Studies: Assessing the therapeutic impact of new drugs or interventions.
  • Pulmonary and Cardiac Research: Detailed assessment of right and left heart function, making it ideal for exploring heart failure, hypertension, and pulmonary diseases.
  • Preclinical Research: Instrumental in understanding the full spectrum of cardiovascular health and disease models.
Endpoint Preclinical Rodent PV Loop Masterclass
Master the Application of Cardiac PV Loops

Our Rodent Pressure-Volume Loop Masterclass delivers an immersive training experience, empowering preclinical researchers with the knowledge, tools and techniques required to maximize PV Loop data accuracy and reproducibility in small-animal models.  Learn More

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  • Training: We offer both on-site and off-site training across all service areas, ensuring your team is fully equipped to perform advanced preclinical techniques.