Overview
Our team’s analysis and interpretation services for ECG and respiratory data provide precise and reliable assessments tailored to the needs of your preclinical research. We specialize in arrhythmia detection, heart rate variability, respiratory function analysis, and rhythm interpretation for both GLP and non-GLP studies.
Importantly, our ECG and respiratory services are designed to meet the specific demands of safety pharmacology, efficacy studies, toxicology assessments, and academic research, ensuring that all relevant cardiorespiratory endpoints are captured efficiently.
Why Endpoint?
We provide comprehensive, compliant, and flexible solutions tailored to the unique demands of preclinical research. Whether you’re conducting GLP safety pharmacology studies, early-stage exploratory research, or academic investigations, we ensure that your data is analyzed with precision and delivered in a format that meets regulatory standards or your research needs. By partnering with us, you can streamline your workflows, maintain research momentum, and ensure rapid turnaround times without compromising quality.
Cardiorespiratory Analysis, Interpretation, and Reporting:
We provide flexible ECG data analysis, covering both manual interval measurements as well as large-scale digital telemetry data sets. Utilizing software such as EMKA ecgAUTO and DSI Ponemah, we process a wide variety of ECG formats, including native EMKA IOX, DSI Ponemah, and DSI ART. We also work with comma or tab-delimited raw data formats from systems like Notocord, BioPac, and ADInstruments. Our team delivers fully GLP-compliant reports tailored to your study requirements, offering both quantitative (PR, QRS, QT, QTc intervals, etc.) and qualitative ECG analysis, with our veterinary cardiologist providing interpretative oversight. Our analyses follow S7B/E14-compliant approaches, ensuring your data meets regulatory standards for cardiac safety pharmacology.
In addition to ECG, we offer respiratory function analysis to support a comprehensive cardiorespiratory assessment. We provide flexible reporting options, capturing key respiratory endpoints such as tidal volume, respiratory rate, and minute ventilation, and delivering clear, accurate data to inform your study conclusions. With robust reporting and fast turnaround times, our services ensure the seamless integration of respiratory data with your ECG findings.
Biostatistics:
Our biostatistics services support advanced ECG and respiratory data analysis through the use of SAS, Prism, and R software, offering highly customizable, GLP-compliant statistical analysis. Whether you require basic summary statistics or more advanced multimodal data integration, we tailor our biostatistical services to meet the precise needs of your study, ensuring that your results are robust, reliable, and ready for regulatory submission or publication.
Applications
Analysis and interpretation of ECG and respiratory data are critical across preclinical research settings, including:
- Discovery: Early-stage insights into cardiorespiratory function in preclinical models.
- Efficacy Studies: Assessing the impact of pharmacological interventions on cardiac electrical activity and respiratory function.
- Safety & Toxicology: GLP-compliant assessments to detect arrhythmias, conduction issues, heart rate variability, and respiratory function, with comprehensive reports.
- Cardiovascular Research: Understanding electrical and respiratory function in models of arrhythmias, ischemia, heart failure, and pulmonary diseases.
- Respiratory Analysis: Integrated ECG and respiratory monitoring for comprehensive physiological assessments.