Safety Pharmacology

Overview

Endpoint Preclinical’s Safety Pharmacology services deliver evaluation of cardiovascular, respiratory, and central nervous system functional endpoints in support of development programs. We partner with CROs, pharmaceutical companies, medical device developers, biotech firms, and academic laboratories to optimize study design, strengthen signal acquisition, and provide structured interpretation suitable for regulatory submission.

Our expertise spans standalone core battery studies conducted under GLP as well as cardiorespiratory endpoints incorporated within repeat-dose toxicology programs. By integrating advanced telemetry implantation, board-certified cardiovascular interpretation, quantitative analytics, and regulator-ready reporting, Endpoint functions as an extension of your internal team, ensuring high-fidelity physiologic data and consistent interpretation across reviewers and time points.

Advanced telemetry
Core battery CV assessment
Integrated respiratory endpoints
GLP reporting & biostats
Study design & regulatory

Advanced telemetry
Core battery CV assessment
Integrated respiratory endpoints
GLP reporting & biostats
Study design & regulatory

Service Highlights

Below is a selection of our offerings. If you do not see your specific need listed, please contact us. We tailor our support to your program design and regulatory objectives.

Advanced Telemetry Implantation & Signal Optimization: Our surgical experts have helped refine telemetry methodologies across major platforms including DSI, EMKA, Kaha, and others. With experience spanning through small to large research models, we optimize implantation strategy, lead placement, and perioperative management to improve signal fidelity, reduce artifact, and deliver actionable data. We also provide customized on-site training to strengthen internal laboratory capabilities.
Core Battery Cardiovascular Assessment: Our experts specialize in qualitative and quantitative ECG evaluation aligned with safety pharmacology expectations. Programs include detailed interval measurements including PR, QRS, QT, QTc, and RR, along with rhythm assessment, arrhythmia detection, heart rate analysis, and blood pressure integration when collected. Interpretation includes focused assessment of ventricular repolarization and QT interval changes relevant to proarrhythmia risk. Board-certified cardiology oversight ensures defensible interpretation within the context of study design and regulatory relevance.
Integrated Respiratory Assessment: Respiratory endpoints are evaluated with the same rigor applied to cardiovascular data. Quantitative analysis of respiratory rate, tidal volume, and minute ventilation is paired with artifact recognition and signal validation. Cardiorespiratory integration strengthens physiologic interpretation and supports clear safety conclusions.
Quantitative Analytics & GLP Reporting: Safety pharmacology requires structured documentation aligned with regulatory expectations. Endpoint delivers validated quantitative analysis using platforms such as SAS, R, and Prism, generating tables, figures, and integrated summaries suitable for inclusion in regulatory submissions. Qualitative interpretation and statistical outputs are aligned to ensure consistency across reviewers and reporting cycles.
Supplemental Neurophysiology & Secondary Imaging Support: When warranted by study findings or development strategy, Endpoint provides targeted EEG interpretation and CNS-focused physiologic assessment. Board-certified radiologists are available for secondary imaging review to clarify structural or mechanistic questions that arise during safety evaluation.
Study Design & Strategic Consultation: Early involvement reduces downstream variability. We advise on telemetry platform selection, implantation planning, acquisition parameters, and endpoint prioritization to align physiologic assessments with development objectives.

Meet our Experts!

Endpoint’s Safety Pharmacology services are delivered by internationally recognized specialists with extensive experience in telemetry refinement, cardiovascular interpretation, quantitative analytics, and GLP reporting.

Stacy Hosking, DVM, DACVIM (Cardiology)

Expert in Echocardiography, ECG Analysis, and Cardiovascular Consulting. View Profile

Ray Chui, PhD, DSP

Expert in Cardiovascular and Respiratory Data Analytics, Safety Pharmacology, Toxicology, and GLP Compliance. View Profile

Joel Baublits, MS

Expert in Biostatistics, Multimodal Data Analysis, Respiratory & Toxicology Studies. View Profile

Leslie Stoll, SRS, LVT, LATG

Expert in Higher-Order Surgical Research Models, Device Implantation & Perioperative Care. View Profile

Brad Gien, BSc, CM

Expert in Production-Level Surgical Services, Preclinical Model Development, and Training. View Profile

Oliver Wearing, PhD

Expert in Cardiovascular Physiology & Preclinical Microsurgery. View Profile

Why Endpoint?

Endpoint Preclinical integrates advanced telemetry expertise, board-certified cardiovascular interpretation, and high-volume quantitative analytics to strengthen physiologic data quality and reporting consistency.

Our surgical specialists have contributed to refinement of modern telemetry methodologies that improve signal reliability in instrumented models. Our cardiology and analytics teams provide structured, regulator-ready interpretation that aligns qualitative review with quantitative outputs. Whether we are strengthening your laboratory team on-site or supporting your programs through remote consultation, we help ensure consistent safety evaluation across studies and development phases.

Safety Pharmacology