Ventricular PV Loops

Overview

Endpoint Preclinical’s Pressure-Volume (PV) Loop Analysis service offers a comprehensive evaluation of cardiac contractility and performance by capturing both load‑dependent and load‑independent indices. This gold-standard technique reveals subtle changes in myocardial function—providing essential endpoints for device development, therapeutic assessments, and regulatory evaluations.

The service supports preclinical research across diverse models while offering flexible equipment access, allowing you to utilize our advanced PV loop systems or your own devices for high‑quality, reproducible data.

LV and RV function
Technology access
Comprehensive cardiac assessment
World-class training

LV and RV function
Technology access
Comprehensive cardiac assessment
World-class training

Service Highlights

Find key information about our cardiac PV Loop services below. If you don’t see what you’re looking for, please contact us—we can likely help!

Comprehensive Data Endpoints: Nuanced measurements of cardiac performance capture both load‑dependent and load‑independent metrics, illuminating subtle functional changes often missed by other methods.
Flexible Equipment Access: Advanced PV loop systems can be deployed on‑site or integrated with existing lab infrastructure, enabling high‑fidelity data collection for research spanning discovery studies to cardiac and pulmonary assessments.
Left & Right Ventricular Assessments: Protocols are easily adapted to evaluate either LV or RV function, accommodating diverse physiological or pathological models.
Cardiac & Pulmonary Function Insight: Whether investigating disease progression, therapeutic efficacy, or device performance, PV loop data delivers critical insights essential for data‑driven decision‑making.
On‑Site Expertise & Technology Rental: Rapid deployment of skilled professionals and PV loop instrumentation ensures real‑time support, even in labs with limited infrastructure.
Hands‑On Training Sessions: Tailored instruction equips teams with best practices for consistent, high‑quality data acquisition, while consultation services help refine protocols to match specific study goals.

Meet our Pressure-Volume Loop Experts!

Tim Hacker, PhD

Expert in Cardiovascular Models, Advanced Sonography, and Hemodynamic Data Analysis. View Profile

Oliver Wearing, PhD

Expert in Cardiovascular Physiology & Preclinical Microsurgery. View Profile

Why Endpoint?

Endpoint Preclinical delivers fully integrated PV loop solutions, from deploying state-of-the-art instrumentation to customizing protocols for unique disease models. Our experts excel in load-independent analysis, uncovering subtle functional differences that traditional endpoints miss. By combining targeted training, robust data analysis, and flexible equipment configurations, we ensure consistent, top-tier results for device validation, therapeutic efficacy testing, or discovery-phase research.

Master the Application of Cardiac PV Loops

Our Rodent Pressure-Volume Loop Masterclass delivers an immersive training experience, empowering preclinical researchers with the knowledge, tools and techniques required to maximize PV Loop data accuracy and reproducibility in small-animal models. Learn More

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Ventricular PV Loops