A renowned authority in cardiovascular research with over 30 years of experience, Dr. Tim Hacker specializes in developing preclinical cardiovascular models, advanced sonography, and hemodynamic data analysis, driving advancements in cardiac disease research and therapeutic development.

Endpoint Preclinical is pleased to welcome Dr. Tim Hacker, Ph.D., to our Expert Network. With a career spanning three decades, Dr. Hacker has held roles such as Director of the Cardiovascular Physiology Core Laboratory at the University of Wisconsin-Madison. His work has contributed to over 100 studies supporting regulatory filings, clinical trials, and peer-reviewed publications. Dr. Hacker’s expertise includes developing preclinical cardiac models, advanced imaging techniques, and functional hemodynamic analysis. View Tim’s Profile

While experienced in a wide range of preclinical cardiovascular techniques and research models, Dr. Hacker excels in three key areas:

• Creating Cardiovascular Disease Models: Dr. Hacker has developed and refined preclinical models for cardiac conditions such as myocardial infarction, pressure overload, pulmonary hypertension, and heart failure. His expertise includes acute and chronic interventions to simulate disease states, providing reproducible models for drug development and device testing.
• Echocardiography: Dr. Hacker is a leading expert in echocardiographic imaging, offering capabilities such as on-site data collection, off-site analysis, and customized endpoint determination. His work includes advanced imaging for ventricular performance, valve function, and blood flow analysis. Specialized in HFpEF, HFrEF, pulmonary hypertension, and hypertrophic cardiomyopathy models, Dr. Hacker ensures precise imaging for complex research needs.
• Ventricular Pressure-Volume (PV) Loops: With extensive experience in catheter-based techniques, Dr. Hacker provides expertise in PV loop data acquisition and analysis. This includes assessing both load-dependent and load-independent measures of cardiac function, enabling detailed evaluation of therapeutic effects and disease progression.

Dr. Hacker emphasizes the integration of imaging and physiologic monitoring to enhance preclinical study outcomes. He has expertise in:

• Non-Invasive Imaging: Applications of advanced ultrasound systems (e.g., VevoLab) for mouse phenotyping and disease progression studies.
• Physiologic Monitoring: Hemodynamic assessments combining echocardiography and catheter-based techniques.
• Customized Reporting: Generating detailed, reproducible study reports for regulatory filings and client needs.

Dr. Hacker has over 25 years of experience mentoring researchers in advanced surgical and imaging techniques. As a trainer, he provides hands-on guidance in echocardiographic data collection, PV loop analysis, and functional hemodynamics, enabling research teams to independently perform complex protocols with precision.

Dr. Hacker’s contributions support diverse preclinical research applications, including:

• Cardiovascular and Pulmonary Models: Advancing understanding of heart failure, hypertension, and cardiomyopathies.
• Efficacy Studies: Assessing therapeutic impacts on ventricular function and cardiac remodeling.
• Safety and Toxicology Assessments: Identifying cardiac risks in new therapies and devices.

Join us in welcoming Tim, and contact us today to learn how Dr. Hacker and Endpoint Preclinical can support your next study.