With over a decade of experience, Dr. Oliver Wearing specializes in cardiovascular physiology, ventricular pressure-volume loop analysis, and advanced microsurgical techniques, driving the development of preclinical models for cardiovascular and neural systems.

Endpoint Preclinical is excited to welcome Oliver Wearing, Ph.D., to our Expert Network. Dr. Wearing’s career spans significant contributions to preclinical cardiovascular research, including expertise in ventricular pressure-volume (PV) loop data collection, telemetry implantation, and advanced microsurgery. His work supports integrative cardiovascular and neuroscience studies, emphasizing precise data collection and analysis to drive advancements in therapeutic research. View Oliver’s Profile

Ventricular Pressure-Volume Loops: Dr. Wearing is a recognized expert in ventricular PV loop analysis, which provides detailed insight into cardiac function by measuring load-dependent and load-independent parameters. His work includes:

• Data Acquisition and Analysis: Leveraging advanced admittance/conductance technologies to capture nuanced changes in cardiac contractility and performance.
• Acute and Chronic Measurements: Supporting both short-term interventions and long-term studies to monitor disease progression and therapeutic efficacy.
• Left and Right Ventricular Function: Specializing in detailed assessments of both right and left ventricular performance, critical for research into heart failure, hypertension, and pulmonary diseases.
• Applications Across Research Areas: Using PV loops in discovery studies, efficacy assessments, and safety evaluations, Dr. Wearing provides invaluable data for advancing cardiovascular and pulmonary research.

Dr. Wearing also serves as the lead instructor for Endpoint’s Rodent PV Loop Masterclass, providing hands-on training to researchers seeking to master PV loop techniques. His expertise ensures researchers gain the skills needed to generate high-quality data from this critical methodology.

Microsurgical Procedures: With advanced training in vascular and cardiac microsurgery, Dr. Wearing performs complex surgical interventions, including:

• Vascular Catheterization: Techniques for blood pressure monitoring and sympathetic nerve activity recording.
• Telemetry Implantation: Long-term physiological monitoring using ADInstruments KAHA and DSI telemetry systems.

A passionate mentor, Dr. Wearing will be available for both virtual consultation services and on-site training focused on optimizing microsurgical procedures, improving PV Loop data acquisition, and helping clients with implantable telemetry studies.  All of his training services will focus on:

• Enhancing technical proficiency in surgical and analytical methods.
• Promoting reproducibility and precision in data collection, while embracing 3Rs principles.
• Empowering researchers to achieve independence in complex preclinical procedures.

Join us in welcoming Dr. Oliver Wearing to Endpoint Preclinical. His specialized skills in cardiovascular physiology, PV loop analysis, and microsurgery strengthen our ability to deliver innovative solutions and high-quality outcomes for clients. Contact us to learn how Dr. Wearing can support your research.