Rodent Pressure-Volume Loop Masterclass
A comprehensive, multi-day training program on rodent cardiac PV Loops for preclinical researchers.
Hosted by Dr. Chris West in his Translational Integrative Physiology Laboratory at the University of British Columbia Okanagan, the Endpoint Preclinical Rodent Pressure-Volume Loop Masterclass combines lectures and on-demand resources with immersive classroom and hands-on laboratory training. This program aims to empower preclinical researchers with the knowledge, tools and techniques required to maximize PV Loop data accuracy and reproducibility in small-animal models.
Topics:
- Fundamental cardiovascular and hemodynamic principles
- History and current landscape of PV Loop and supporting technologies
- Conductance and Admittance volume calibration procedures
- Correct curve fitting of occlusion data and selection of load-independent indices
- How to optimize grouped occlusion data analysis
- Best-practices for data visualization and statistical presentation
- How to set up, prepare, and execute successful rodent PV Loop surgeries
- Monitoring and controlling anesthesia, respiration, and body-temperature
- Hands-on training for open- and closed-chest surgeries in a rat model
- Correct catheter insertion, navigation, and placement in the ventricle
- Modern data collection best practices, ensuring accuracy and reproducibility
- How to adjust preload and afterload in both open- and closed-chest models
Cost:
Academic Rate: Single – $4,800, or Pair – $9,000
Industry Rate: Single – $5,800, or Pair – $10,200
Pricing is USD. Pair rate is for two colleagues that wish to share a single surgical station.
Instructors:
Chris West, PhD
Associate Professor,
Department of Cellular and Physiological Sciences,
Centre for Chronic Disease Prevention and Management,
Faculty of Medicine, UBC Okanagan
Chris West is a leading expert in Pressure-Volume Loop applications, specializing in integrative and translational physiology. With over 15 years of experience, Chris’s research has significantly advanced the field of cardiovascular physiology through his exploration of the sympathetic nervous system’s role in heart function and cardiorespiratory interactions, using both human and animal models. A significant focus of his work has been on spinal cord injury, where he has pioneered interventions to restore sympathetic support to the cardiovascular system, including intermittent hypoxia/hypercapnia, spinal cord stimulation, and exercise. Chris has also developed innovative animal models that enable the simultaneous and precise assessment of heart and vascular function alongside neural outflow from the sympathetic nervous system. Recently, Chris has spearheaded a collaboration with leading experts across North America to establish field-standard guidelines for conducting Pressure-Volume Loop studies. This work not only ensures a modern understanding of the field but also sets new standards for its advancement.
Oliver Wearing, PhD
Research Associate,
Translational Integrative Physiology Laboratory,
Department of Cellular and Physiological Sciences,
Faculty of Medicine, UBC Okanagan
Oliver has been employing invasive surgical techniques for over a decade. He specializes in ventricular pressure-volume data collection and analysis, demonstrating strong capabilities in both acute and chronic measurements of blood pressure, sympathetic nerve activity, blood flow, and overall hemodynamics. His work is informed by advanced microsurgical techniques, having been trained by leading experts worldwide, and includes applying these techniques to model physiological and pathological conditions across various species. With a passion for PV Loop science, Oliver is dedicated to mentoring new researchers and supporting the broader scientific community. He collaborates closely with Dr. Chris West, contributing significantly to the collection and interpretation of Pressure-Volume Loop data. Oliver is enthusiastic about guiding others in the field and advancing cardiovascular research through shared expertise.
